Organelle · stacked cisternae
Golgi apparatus
The post office
In view
Cargo from the ER gathers in small intermediate clusters, then moves on to the cis face. Tiny COPI vesicles bud from the rims to carry enzymes back while the sacs themselves mature from cis to trans, and the lacy trans-Golgi network buds clathrin-coated vesicles.
A stack of 5–7 curved, flattened sacs. Proteins from the ER arrive at the cis face, have their sugar tags trimmed and rebuilt as they pass from sac to sac, and are sorted at the trans face into vesicles bound for the membrane, the lysosomes or the outside world.
In human cells, thin membrane tubules join neighbouring stacks side by side into one ribbon next to the centrosome.
- Cisternae
- 5–7 per stack
- Direction
- cis → trans
- Location
- Beside the centrosome
- Discovered
- 1898 · Camillo Golgi
Did you know?
Golgi found it with a silver stain in 1898. For half a century many scientists dismissed it as an artefact, until electron microscopes proved it real in the 1950s.
Sources
- COPII-coated vesicles: flexible enough for large cargo? · Fromme & Schekman 2005 · Current Opinion in Cell Biology
- The ER-Golgi intermediate compartment (ERGIC): in search of its identity and function · Appenzeller-Herzog & Hauri 2006 · J Cell Sci
- Models for Golgi traffic: a critical assessment · Glick & Luini 2011 · Cold Spring Harb Perspect Biol
- The structure of the COPI coat determined within the cell · Bykov et al. 2017 · Elife
- Golgi structure in three dimensions: functional insights from the normal rat kidney cell · Ladinsky et al. 1999 · J Cell Biol
- Cell cycle regulation of Golgi membrane dynamics · Tang & Wang 2013 · Trends Cell Biol
- 4.4 The Endomembrane System and Proteins · OpenStax · Biology 2e
- The Golgi Apparatus · Cooper 2000 · The Cell: A Molecular Approach, 2nd ed.
- The Golgi and the centrosome: building a functional partnership · Sütterlin & Colanzi 2010 · J Cell Biol
- Camillo Golgi and the discovery of the Golgi apparatus · Dröscher 1998 · Histochemistry and Cell Biology
- Camillo Golgi (1843–1926) · Embryo Project Encyclopedia
- How Camillo Golgi became “the Golgi” · Mazzarello et al. 2009 · FEBS Letters