Organela · mreža cevčica

Glatki endoplazmatični retikulum

Kuhinja lipida i centar za detoksikaciju

U kadru

Cevčice se njišu, a s vremena na vreme izraste nova, poveže se s mrežom i kasnije se ponovo odvoji: mreža ER-a se neprestano preuređuje.

Deo ER-a bez ribozoma je mreža cevčica koje se sastaju u trokrakim čvorovima. Pravi većinu membranskih lipida ćelije, a u ćelijama koje luče hormone pravi i steroide.

U ćelijama jetre prepun je enzima citohroma P450 koji neutrališu lekove i otrove. U svakoj ćeliji služi kao rezervoar kalcijuma.

Pravi

lipide · steroide

Detoksikacija

citohrom P450

Ca²⁺ unutra

≈ 2.500× više nego u citosolu

U mišićima

sarkoplazmatični retikulum

Da li ste znali?

Ako jetra nekoliko dana dobija fenobarbital, njen glatki ER se umnožava dok ne preovlada u citoplazmi i tako pojača detoksikaciju.

Izvori

1. Increased spatiotemporal resolution reveals highly dynamic dense tubular matrices in the peripheral ER · Nixon-Abell et al. 2016 · Science
2. Dynamic behavior of endoplasmic reticulum in living cells · Lee & Chen 1988 · Cell
3. A class of dynamin-like GTPases involved in the generation of the tubular ER network · Hu et al. 2009 · Cell
4. The endoplasmic reticulum: structure, function and response to cellular signaling · Schwarz & Blower 2016 · Cell Mol Life Sci
5. How big is the endoplasmic reticulum of cells? · Milo & Phillips · Cell Biology by the Numbers
6. Syntaxin 17 is abundant in steroidogenic cells and implicated in smooth endoplasmic reticulum membrane dynamics · Steegmaier et al. 2000 · Mol Biol Cell
7. Correlated morphometric and biochemical studies on the liver cell. II. Effects of phenobarbital on rat hepatocytes · Stäubli et al. 1969 · J Cell Biol
8. Studies on the resolution of subcellular free calcium concentrations: a technological advance. Focus on "detection of differentially regulated subsarcolemmal calcium signals activated by vasoactive agonists in rat pulmonary artery smooth muscle cells" · Xu et al. 2014 · Am J Physiol Cell Physiol
9. Intracellular Membrane Contact Sites in Skeletal Muscle Cells · Serano et al. 2025 · Membranes (Basel)